Biased Signaling in Physiology, Pharmacology and Therapeutics

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As a beginning to this book, I would like to take a brief moment to explain the motivation and objectives of this text. The ultimate objective of the book is to provide a single but comprehensive source of information (for both personal and educational purposes) concerning signal transduction as it is understood in the present with the addition of a personal vision on receptor signaling.

The first chapter is purposefully basic and intended to provide both a general historical backdrop and description of basic pharmacological principles as a launching point to the more detailed descriptions of other topics provided by my co-authors. As the focus of the book is on common themes in receptor signaling across classes of receptors, there are natural redundancies apparent from chapter to chapter. With limited space, we have attempted to provide a comprehensive view of the field including understanding how we can model and assess signaling bias in the practical sense. I am motivated to put these topics together in order to provide a more complete view of how we envision receptor signaling and to put it in the context of evolution and a more universal view of receptor signaling. That is, despite clear and significant differences between classes of receptors, there are also universal principles to their function that have been selected and carried forward throughout evolution.

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