Pharmacology of Immunosuppression: Vol 272

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This volume of The Handbook of Experimental Pharmacology provides insights into the broad range of immunosuppressive agents used to modulate immune responses against organs of the body. Given the complexity of the immune pathways involved and their interplay, taming the immune system to treat and control a multitude of naturally occurring diseases and diseases that are a consequence of modern lifesaving therapies such as solid organ and bone marrow transplantation is truly remarkable. The volume begins with a detailed review of salient immune pathways involved in the alloimmune response as well as immune responses to infections, malignancies, and other threats. The subsequent chapters then discuss how these pathways go awry in patients, resulting in autoimmune diseases, and how these pathways are controlled in these autoimmune diseases (rheumatic and multiple sclerosis) using immunosuppression. A further discussion relates to how immunosuppression improves clinical outcomes in these patients through modulation of the immune system.

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