Adaptive Design Theory and Implementation Using SAS and R - 2nd Ed (2014)

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In this revision, I have added 12 new chapters, including Chapter 6, Adaptive Noninferiority Design with Paired Binary Data; Chapter 7, Adaptive Design with Incomplete Paired Data; Chapter 12, Blinded and SemiBlinded Sample-Size Reestimation Design; Chapter 13, Adaptive Design with Coprimary Endpoint; Chapter 15, Pick-the-Winners Design; Chapter 16, The Add-Arm Design for Unimodal Response; Chapter 18, BiomarkerInformed Adaptive Design; Chapter 23, Bayesian Design for EfficacyToxicity Trade-Off and Drug Combination; Chapter 24, Bayesian Approach to Biosimilarity Trial; Chapter 25, Adaptive Multiregional Trial Design; Chapter 26, SAS and R Modules for Group Sequential Design; and Chapter 27, Data Analysis of Adaptive Trial.

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