Lantibiotics As Alternative Therapeutics (2023) Pdf Free Download

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The development of antibiotic resistance has now reached a point of crisis, and innovative methods and application of novel compounds and methods are required to prevent the spread of drug resistant infections in both cases of community and nosocomial environments. Such novel compounds exhibit different modes of action compared to the currently used mechanism of therapeutics to combat resistant organisms. The production of ribosomally synthesized antimicrobial peptides produced by bacteria is also referred to as bacteriocins that act as an alternative to the existing antibiotics. The various types of peptides consist of diverse groups comprising Class I bacteriocins, which are mostly the modified amino acids, after translation, which have developed great importance as pharmaceutical products. The groups of lantibiotics exhibit their activity predominantly against the Grampositive group of bacterial cells, which also includes various drug-resistant organisms such as methicillin-resistant Staphylococcus aureus, vancomycin-intermediate S. aureus, and vancomycin-resistant Enterococci.
Different groups of the antimicrobial peptides demonstrated excellent in vivo activities and have resulted in clinical evaluation for the treatment of life-threatening diseases. Although they possess various positive attributes, they also possess some limitations that include instability, insolubility at physiological pH, low production levels, and susceptibility to proteolytic degradation. The implementation of various technologies comprising genome mining, as well as high-throughput screening strategies for both in vivo and in vitro expressions, has provided a large amount of information relating to the existence of various types of structurally and functionally diverse lantibiotics

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