Self-controlled case series studies (2018) Pdf Free Download

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For several years after its publication in 1995, the self-controlled case series (SCCS) method met with a degree of scepticism. Gradually, it gained credence beyond its early core of advocates, especially among epidemiologists concerned with vaccine safety – the subject area in which the method was originally developed. Helped on by the increasing use of pre-existing databases of patient records in epidemiological research, the SCCS method also became more popular in non-vaccine pharmacoepidemiology.

Back in the early days, we spent much time presenting and popularising the SCCS method. Today, self-controlled methods are more widely accepted by epidemiologists, so this purpose has become less salient. Equally important, in our view, is the need to convey a better understanding of the method – and thus, hopefully, to motivate further methodological developments to extend its range of application and mitigate its limitations. Over the past 20 years, we have provided practical advice to statisticians and epidemiologists who have approached us with queries about the method.

Indeed several of these interactions have blossomed into long-term collaborations, and a few have motivated substantial methodological extensions.

Enriched by this experience, we think that the time is now ripe to collect together a dispersed literature into a coherent narrative. Hence this book, and its associated R package SCCS.

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