Statistical methods in drug combination studies (2015)

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Over the past decades, the development of combination drugs has attracted a great deal of attention from researchers in pharmaceutical and biotechnology industries, academia, and regulatory agencies. The growing interest in using combination drugs to treat various complex diseases has spawned the development of many novel statistical methodologies. The theoretical development, coupled with advances in statistical computing, makes it possible to apply these emerging statistical methods in in vitro and in vivo drug combination assessments. However, despite these advances, there is no book serving as a single source of information of statistical methods in drug combination research, nor is there any guidance for experimental strategies. Bringing together recent developments, conventional methods as well as a balanced perspective of researchers in the industry, academia, and regulatory agency, this book provides a comprehensive treatment of the topic. As drug combination is likely to continue to grow as a key area for innovative drug research and development, it is conceivable that this book will be a useful resource to practitioners in the field.

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