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The development and use of statistical methods has grown exponentially over the last two decades. Nowhere is this more evident than in their application to biostatistics and, in particular, to clinical medical research. To keep abreast with the rapid pace of development, the journal Statistics in Medicine alone is published 24 times a year. Here and in other journals, books and professional meetings, new theory and methods are constantly presented. However, the transitions of the new methods to actual use are not always as rapid. There are problems and obstacles. In such an applied interdisciplinary eld as biostatistics, in which even the simplest study often involves teams of researchers with varying backgrounds and which can generate massive complicated data sets, new methods, no matter how powerful and robust, are of limited use unless they are clearly understood by practitioners, both clinical and biostatistical, and are available with well-documented computer software.
In response to these needs Statistics in Medicine initiated in 1996 the inclusion of tutorials in biostatistics. The main objective of these tutorials is to generate, in a timely manner, brief well-written articles on biostatistical methods; these should be complete enough so that the methods presented are accessible to a broad audience, with sufficient information given to enable readers to understand when the methods are appropriate, to evaluate applications and, most importantly, to use the methods in their own research. At last tutorials were solicited from major methodologists.
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