Application of Peptide-Based Prodrug Chemistry in Drug Development (2013) Pdf Free Download

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Macromolecular (specifically peptide-based) drugs could potentially be highly effective medicines. However, they have a relatively short duration of action and variable therapeutic index. An example of such a peptide is Glucagon-like Peptide I which could potentially be used as a revolutionary drug for diabetes. This is because it stimulates insulin only when the blood glucose level is high thereby reducing the risk of hypoglycemia (a significant disadvantage of using insulin is that an insulin overdose is the single most potent cause of life-threatening hypoglycemia). However its short duration of action (half-life of 2 min in plasma) precludes its therapeutic use.

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