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Over the past three decades the field of immunotoxicology, the study of the effects of exposure to drugs, chemicals, or physical/environmental agents on the structure and function of the immune system has benefited from an increasingly detailed understanding of the cellular and molecular basis of innate and acquired immunity. Arguably one of the most promising areas of investigation centers on the intensely complex network of biochemical regulators, namely the cytokines (and, to a lesser degree, their biochemical cousins the chemokines). Cytokines facilitate the initial recognition of foreignness that launches innate host defenses, they form the bridge that allows a nonspecific response to mature into an antigen-specific acquired immune response, and they maintain this response for the life of the individual. Clearly, any event that affects the biology of these important molecules is likely to have significant effects on the overall immune competence of the host.
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