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Microarrays have become a central tool used in modern biological and biomedical research. This book concerns expression microarrays, which for the remainder of the book, we simply refer to as microarrays. They are tools that permit quantification of the amount of all mRNA transcripts within a particular biological specimen. There are several different technologies for producing microarrays that have different strengths and weaknesses. These platforms and alternatives are discussed in Chapter 1 by Gaffney et al.

Viewed as “hot” and highly exotic tools as recently as the late 1990s, they are now ubiquitous in biological research and the modern biological researcher can no more be unaware and unexposed to microarray research and its results than one can remain ignorant of clinical trials, questionnaire studies, genome scans, animal models, or any of the other tools that have become standard parts of our armamentarium. Although much development in microarray research methodology is still needed, it is clear that microarrays are here to stay.

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