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The industrialisation of any synthetic process is a challenging endeavour, and this is particularly so for pharmaceutical agents because of their relative complexity. In addition to being efficient and atom economic, reactions used on scale to produce pharmaceuticals need to meet exacting safety and environmental standards, while the efficiency of every operation in the work-up, isolation and purification of the reaction needs to be examined. One of the key goals of process research and development (R&D) scientists is to ensure that their processes are economic. Because the price of pharmaceuticals falls sharply when their patents expire, there is a common misconception that they are overpriced by their innovator companies during their patent lifetime. The reality is usually very different: the pharmaceutical development process is both extremely costly and risky. There is no law of economics stating that the launch of a product onto the market ensures that it will be profitable, and it has been estimated that over half of all drugs that reach the market fail to recoup their discovery and development costs. Hence, process R&D scientists are charged with driving down the cost of goods of drug candidates, to help ensure their commercial viability.

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