Pharmaceutical Salts and Co-crystals (2011) Pdf Free Download

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Multi-component crystalline systems are not new, but only recently has the term co-crystal (or cocrystal) gained momentum in the glossary of the pharmaceutical world. In contrast to salts, formation of a co-crystal can be envisaged for any active pharmaceutical ingredient (API), regardless of the presence of acidic or basic groups, thus enlarging the pharmaceutical space associated with an already marketed drug or a drug candidate. Indeed, making pharmaceutical co-crystals allows modifications to be introduced to the crystalline form of an API, which in turn can alter its physicochemical properties, without compromising its intended biological activity. In this context, one excellent reason, among others, to investigate co-crystals is to increase the solubility or the dissolution properties of a poorly soluble API. For neutral APIs, co-crystals can potentially expand the number of solid forms in development, while for a free acid or free base, the approach of selecting of both salts and co-crystals can be used to improve the solubility profile.

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