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Sex and gender differences in frequent diseases are more widespread than one may assume. In addition, they have significant yet frequently underestimated consequences on the daily practice of medicine, on outcomes and on choice and efficacy of therapies. Using gender-based approaches improves the quality of medical care. Understanding differences in symptoms of myocardial infarction and help-seeking behaviour in women and men leads to a more efficient and faster therapy in both genders. Knowing, for example, that exercise ECG has different sensitivity in subgroups of women and men lowers the threshold to use additional imaging procedures in subgroups of women with suspected cardiac ischemia. The knowledge that a drug has more adverse effects in one gender will affect dosing and choice of therapy. Knowing that some prevention strategies are more voluntarily accepted in women or men will lead to the design of gender-specific campaigns that are more efficient than global approaches.
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