The Serotonin Receptors (2006) Pdf Free Download

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It has been nearly 20 years since the last Humana Press book devoted to serotonin (5-hydroxytryptamine; 5-HT) receptors has appeared. Since then, the field of 5-HT receptors has undergone a revolution due to the discovery of many additional 5-HT receptors. Although 5-HT was chemically elucidated in 1948 by Page and colleagues (Rapport et al., 1948) and 5-HT receptors initially classified in 1957 (Gaddum and Picarelli, 1957), the complexity of 5-HT pharmacology was not fully appreciated until the late 1970s and early 1980s when many putative 5-HT receptors were identified by radioligand binding studies (e.g., 5-HT1A, 5-HT2, 5-HT1E and so on) (Leysen et al., 1979; Hamon et al., 1980; Peroutka et al., 1981; Leonhardt et al., 1989). The first 5-HT receptors were cloned in 1988 (Fargin et al., 1988; Julius et al., 1988) and the discovery of 14 distinct human 5-HT receptors since then ushered in the era of 5-HT receptor molecular biology (Kroeze et al., 2003). The cloning and sequencing of 5-HT receptors has also revealed the presence of post-transcriptionally modified mRNA species (RNA editing) (Burns et al., 1997) as well as naturally occurring mutations and their relations to various diseases (e.g., single nucleotide polymorphisms; SNPs) (Arranz et al., 1995).

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