Transient Receptor Potential (TRP) Channels (2007) Pdf Free Download

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Features of Transient Receptor Potential (TRP) Channels (2007) PDF free download:

Only a decade has passed since the first mammalian homologues of the transient receptor potential (TRP) gene from Drosophila melanogasterwere discovered. Today the superfamily of mammalian TRP genes comprises 28 members. Most if not all of them encode ion channel proteins, and these TRP cation channels display an extraordinary assortment of selectivities and activation mechanisms, some of which represent previously unrecognized modes for regulating ion channels. The biological roles of TRP channels appear to be equally diverse. Some TRPs are involved in sensory functions such as smell, taste, primitive forms of vision, pheromone sensing and pain perception. Found in skin, hair follicles and nerve cells, the "thermo"-TRPs are responsive to heat or cold and may help regulate body temperature and avoidance of tissue-damaging noxious temperatures. Other TRPs are also sensitive to the active ingredients of oregano, thyme and clove, allicin, mustard, horseradish and wasabi, cinnamon oil and chili peppers. Some of those natural compounds or their ingredients have been in medical (and kitchen) use for centuries.

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