APOPTOSlS (1997) Pdf Free Download

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Physiological cell death is essential for the appropriate development and function of multicellular organisms. Unnecessary, damaged, and potentially harmful cells must be deleted from surrounding healthy cells to ensure structural and functional tissue homeostasis. Examples of physiological cell death have been observed in nearly every cell type throughout development and maturation. During embryological development, a genetically defined spatiotemporal program of cell proliferation and cell death (often referred to as programmed cell death) ensures appropriate cellular patterning and organogenesis. In adult tissues, physiological cell death also figures prominently, notably within cyclically stimulated or hormone-dependent tissues, such as the endometrium, prostate, adrenal, and mammary gland, but also in “steady-state” turnover in many other tissues. 

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