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Since the first benzodiazepines were introduced to the market in 1960, there has been an evolution of these drugs toward lower dosage, shorter action, and faster clearance. As a consequence, this new generation of benzodiazepines eluded detection in many laboratories. Benzodiazepines can be abused in several different ways. These drugs are often given in conjunction with alcohol to enhance the desired effect, thus requiring lower doses. This situation has created added challenges to the toxicologist. Use of normal screening and confirmation methods may not detect the lower levels of these drugs, and in some cases the laboratory may not have capability in the methodologies to detect a particular drug.
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