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This book, on the nervous system, is the sixth volume of a set prepared under the sponsorship of the International Life Sciences Institute (ILSI). One aim of this set on the Pathology of Laboratory Animals is to provide information which will be useful to pathologists, especially those involved in studies on the safety of foods, drugs, chemicals, and other substances in the environment. It is expected that this and future volumes will contribute to better communication, on an international basis, among people in government, industry, and academia who are involved in protection of the public health.
The arrangement of this volume is based, in part, upon the philosophy that the first step toward understanding a pathologic lesion is its precise and unambiguous identification. The microscopic and ultrastructural features of a lesion that are particularly useful to the pathologist for definitive diagnosis, therefore, are considered foremost. Diagnostic terms preferred by the author and editors are used as the subject heading for each pathologic lesion. Synonyms are listed, although most are not preferred and some may have been used erroneously in prior publications. The problems arising in the differential diagnosis of similar lesions are considered in detail. The biologic significance of each pathologic lesion is considered under such headings as etiology, natural history, pathogenesis, and frequency of occurrence under natural or experimental conditions.
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