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This book is a review and high-yield reference on the clinical molecular diagnostics of malignant neoplasms. We aim to address the practical questions frequently encountered in molecular oncology practice, as well as key points and pitfalls in the clinical interpretation of molecular tests in guiding precision cancer management. It uses the Q&A format and case presentations, with emphasis on understanding the molecular test methods, diagnosis, classifcation, risk assessment, and clinical correlation. Starting with an update on the molecular biology of cancer, the book focuses on topics related to molecular diagnostics and genetics-based precision oncology. The molecular methods used in clinical laboratories, from traditional single-gene, single-analyte methods to multiplex, cutting-edge, and high-throughput technologies, are reviewed. Separate chapters are dedicated to the discussion of bioinformatics for the analysis of genetic/genomic data generated from molecular assays and quality control (QC)/quality assurance (QA) programs in the clinical laboratories; both are critical in producing high quality results for clinical care of cancer patients. These are followed by organ system–based reviews and discussions on molecular genetic abnormalities and related tests covering diverse types of common to rare malignant neoplasms
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