Sphingolipids in Disease (2013) Pdf Free Download

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Features of Sphingolipids in Disease (2013) PDF free download:

Until the late 1980s, sphingolipids were believed to represent structural components of the plasma membrane, whose function was to provide a protective barrier to the cell. This picture dramatically changed within the last years. Sphingolipids are now recognized signals for fundamental cellular processes such as proliferation, survival, cell death, adhesion, migration, angiogenesis, and embryogenesis. The explosion of knowledge regarding sphingolipids was facilitated by biochemical studies of their signaling properties, the cloning of enzymes of the sphingolipid metabolism, development of genetic models for determining their physiologic roles, and the establishment of biochemical, biophysical, and optical methods for their detection and quantitation. The next step in the evolution of sphingolipids will be the transfer of basic insights into the biochemistry and cell biology of human disease. The recent success of the sphingolipid drug, Fingolimod, a sphingosine 1-phosphate agonist, which rapidly became a therapy for multiple sclerosis, exemplifies the potential of targeting sphingolipids for the treatment of human disorders. The aim of our two volumes in this series—Sphingolipids: Basic Science and Drug Development and Sphingolipids in Disease—is to define the state of the art of sphingolipid biology and to present preclinical developments and early clinical applications of this fascinating class of lipids.

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