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In the second half of the 20th century innate immune responses of cellular or humoral type were treated like stepchildren by many immunologists: that is, somewhat neglected. This disregard turned into an exciting research field over the past several years and led to the identification of receptor families involved in the recognition of microbes. This has resulted in a remarkable refinement of our understanding of innate immunity as it relates to host defense. Additionally, it has led to the appreciation of the role of the innate immunity in “guiding” the development of the adaptive immune system.
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