Harper's Illustrated Biochemistry

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Cover Illustration for the Thirty-first Edition

The illustration on the cover of the thirty-first edition, the structure of Zika virus protein determined at 3.8 Å resolution, was generously prepared and provided by Lei Sun. The supporting data appeared in: Sirohi D, Chen Z, Sun L, Klose T, Pierson TC, Rossmann MG, Kuhn RJ: “The 3.8 Å resolution cryo-EM structure of Zika virus protein”, Science 2016;352:497-470. Together with the Zika virus, first recovered in the Zika valley of Uganda, the viruses responsible for yellow fever, West Nile fever, and dengue fever are members of the Flavivridae family of positivestrand DNA viruses. The cover illustration indicates the resolving power of cryo-electron microscopy (cryo-EM). More importantly, it recognizes the medical significance of infection by the Zika virus, which in pregnant women can result in a significant risk of congenital microcephaly and associated severe mental impairment. While Zika virus typically is transmitted by the bite of an infected mosquito, emerging evidence suggests that under certain conditions the Zika virus may also be transmitted between human subjects. 

Changes in the Thirty-first Edition

As always, Harper’s Illustrated Biochemistry continues to emphasize the close relationship of biochemistry to the understanding of diseases, their pathology and the practice of medicine. The contents of most chapters have been updated and provide to the reader the most current and pertinent information. Toward that end, we have replaced Chapter 10

“Bioinformatics and Computational Biology,” most of whose programs and topics (for example protein and nucleotide sequence comparisons and in silico approaches in drug design) are available on line or are now common knowledge. Its replacement, new Chapter 10 “Biochemistry of Transition Metals,” incorporates material from several chapters, notably  those of blood cells and plasma, which contained extensive content on metal ion adsorption and trafficking, especially of iron and copper. Since approximately a third of all proteins are metalloproteins, new Chapter 10 explicitly addresses the importance and overall pervasiveness of transition metals. Given the overlap with the topics of protein structure and of enzyme reaction mechanisms, new Chapter 10 now follows the three chapters on enzymes as the final chapter in Section II, now renamed Enzymes: Kinetics, Mechanism, Regulation, & Role of Transition Metals. 

Organization of the Book

All 58 chapters of the thirty-first edition place major emphasis on the medical relevance of biochemistry. Topics are organized under eleven major headings. Both to assist study and to facilitate retention of the contained information, Questions follow each Section. Bank response

The attachment is as follows.

The first section provides a brief history of biochemistry and emphasizes Interactions between biochemistry and medicine. 

IRRIGATION SYSTEMS The importance of intracellular pH homeostasis has been studied and Various commands of protein structure are discussed. The second part begins with a chapter on hemoglobin. Then four chapters Processing kinetics, mechanism of action and metabolic regulation Enzymes and the role of metal ions in several intermediate aspects Metabolism. Volume III deals with the role of bioenergy and high energy Phosphate, oxide reduction in energy capture and transmission Biological oxidation and reactions involved in describing metabolism Energy uptake by the respiratory chain and oxidative phosphorylation. Section IV considers carbohydrate metabolism by glycolysis, Citric acid cycle, pentose phosphate pathway, glycogen

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