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Diabetes mellitus (DM) is a chronic disorder (an excess of glucose levels in blood) because insulin is no longer produced in the pancreas (type I DM) or the body is unable to utilize produced insulin in the body properly (type II DM). DM is the world’s most endemic and mortality causing disease affecting more than 6% of the adult population. The growth rate of DM patients has been increasing rapidly due to different factors such as genetic, environmental, lifestyle, increased calorie intake, and less body exercise. But the development of medication is not as much as the growth rate of DM and its complications. Type I DM has no preventive medicine, but type II can be prevented and controlled by maintaining a healthy lifestyle. However, their complications can be delayed by taking insulin therapy.
The complications of DM have more impact on different metabolisms in the body and are not specific to any particular disease, because insulin is the principal hormone responsible for the uptake of glucose from blood to different cells of the body. DM mainly damages the blood vessels and leads to the preliminary complications in the eyes, kidneys, and nerves. All these complications are interlinked to each other because glucose is the principal fuel for cellular functions. The damage of nerves due to DM is known as diabetic neuropathy (DN); its main symptoms are numbness and tingling that lead to skin damage.
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