GABAReceptor Pharmacology (2010) Pdf Free Download

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Overview of GABAReceptor Pharmacology (2010) PDF free download:

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Features of GABAReceptor Pharmacology (2010) PDF free download:

Studies on g-aminobutyric acid (GABA) receptor systems have yielded an abundance of fundamental information on chemical neurotransmission. For example, characterization of the structure and function of the GABAA receptor provided much of the evidence that ligand-gated ion channels are composed of multiple, interacting subunits. The discovery that the benzodiazepines, one of the most widely used drug classes, enhance GABAA responsiveness by increasing the sensitivity of this site for endogenous GABA provided conclusive proof that allosteric agents can be safe and effective medications. Moreover, the revelation that the stoichiometry and subunit composition of GABAA receptors differ throughout the brain, and that the affinity of these sites for orthosteric and allosteric compounds is a function of these properties, points the way for the development of more selective ligand-gated channel receptor agonists and antagonists.

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