Radiopharmaceuticals_ Chemistry and Pharmacology (2017) Pdf Free Download

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Nuclear medicine exists in two forms which use slightly different technology to produce images of the in vivo distribution of injected radioactive compounds. For routine clinical use single photon emission tomography (SPECT) predominates and uses mainly Technetium-99m. On the other hand, there is an extensive research effort using positron emission tomography (PET), and here Carbon-11, Fluorine-18 and Oxygen-15 are most used. As yet PET has not been widely used in a clinical setting because the radionuclides it uses are short lived and cyclotron produced.

Clinically, nuclear medicine has been viewed as the Cinderella o f medical imaging because it is seen as being ’low tech* (having been around for much longer), is relatively inexpensive to perform, and because the resolution of nuclear imaging devices is inferior to that of the newer CT or MRJ machines.  This means that morphological images obtained by the latter devices are in almost all cases superior. Radiopharmaceuticals have held a similar position relative to therapeutic drugs because of the dominant position of metal complexes which has isolated the practitioners from the main pharmaceutical chemistry population. Coupled with the scarcity of knowledge of the element most frequently used in radiopharmaceutical chemistry, technetium (a result of current stocks of the element being totally man-made), this has generated a view of radiopharmaceutical chemistry as being something of a 'Black Art’ and an imprecise one at that.

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