Bile Acids and Their Receptors (2019) Pdf Free Download

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Bile acids are the end product of cholesterol metabolism in mammals known for their role in nutrient absorption. Bile acids are amphipathic steroids, acting as physiological surfactants that thanks to their molecular arrangement develop a peculiar hydrophilic/lipophilic balance in aqueous solutions facilitating the absorption of dietary fats (lipids and cholesterol) and fat-soluble vitamins through micellar dispersion. In the last 20 years, however, there has been a dramatic increase in the extent of our knowledge regarding the functional role of bile acids driven by the discovery that, similar to other steroids, bile acids are signaling molecules acting on a specific family of receptors highly represented in the gastrointestinal tract and liver.            

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