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It was with great pleasure that I accepted the invitation of Springer to edit this book. My association with the vascular endothelium covers a large part of scientific career and, as with any good long-standing relationship, it has had moments of great excitement and periods of laborious construction. It has sometimes been difficult but has never given me cause for despondency. Indeed, in the last quarter of a century, research on the vascular endothelium has been very productive and its results have contributed, arguably more than any others, to unravelling the mystery of cardiovascular disease, its origin, its development, its complications and its prevention or treatment once it has developed.
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