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It must be hard, nowadays, for students in biomedical disciplines to escape knowing something about nitric oxide (NO). Even among the general public, it must be becoming one of the better-known molecules. It is hard to imagine that little more than a decade ago, NO was the preserve of a small handful of scientists. In the late 1980s, probably about half a dozen laboratories contributed essentially to the discovery that NO was a naturally occurring signal molecule in blood vessels. Three of the leaders of these groups, Robert Furchgott, Louis Ignarro, and Ferid Murad, were awarded the 1998 Nobel Prize for Medicine. Salvador Moncada, another of these pioneers, has kindly contributed the Introduction to this volume.

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