Proteases as Targets for Therapy (2000) Pdf Free Download

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Proteases are a class of enzymes that have been known about for longer than many other enzymes, and the early achieved knowledge about structure and function of proteases had inspired and ease d the elicitation of man y other enzymes. Interest in protease inhibitors soon grew, striking the idea of employing protease inhibitor s for medical therapeutic purposes. Application s, howeve r, wer e not ventured at th at time.The proteases were generally understood to be met abolic ally and cat ab olically active, i.e., digested and rem oved abe rrant protein s by cleaving a wide spectru m of substra tes. Thus, inhibition of indi - vidua l prot eases for th erap eutic purpose appear ed hazardou s, becau se of unpred ictable and possibl y uncontroll abl e conse que nces within the lon g-ran ge chai ns of met abolic reaction s

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